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KMID : 0358420090520010053
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Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 1 p.53 ~ p.60
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Lipid peroxidation and total antioxidant ability in venous plasma and amniotic fluid of pregnant women with preterm premature rupture of membranes
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Lee Kwang-Su
Kim Yoon-Ha
Kim Seok-Mo
Kim Cheol-Hong
Cho Moon-Kyoung
Kim Jong-Woon
Kang Woo-Dae
Park So-Jeong
Cho Hye-Yon
Ahn Bong-Whan
Yang Sung-Yeul
Song Tae-Bok
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Abstract
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Objective: To evaluate their roles in the pathophysiology of preterm premature rupture of membranes (PPROM), we checked interleukin (IL)-6, lipid peroxide, oxygen-radical absorbance capacity (ORAC) and antioxidant vitamin in the venous plasma and amniotic fluid of women with PPROM.
Methods: Venous plasma and amniotic fluid was taken from 20 normal pregnant women and 20 PPROM pregnancy women. IL-6 levels was determined by enzyme-linked immunosorbent assay. Lipid peroxide levels were measured by thiobarbituric acid reaction. The ORAC levels and the antioxidant levels were measured by Cao’s method and by high performance liquid chromatography.
Results: The IL-6 levels in the venous plasma and amniotic fluid of PPROM pregnancy women were significantly higher than normalpregancy (P<0.01, P<0.01). The lipid peroxide levels in the venous plasma and amniotic fluid of PPROM pregnancy women were significantly higher than normal pregancy (P<0.01, P<0.01). The ORAC values in the venous plasma and amniotic fluid of PPROM pregnancy women were significantly higher than normal pregancy (P<0.01, P<0.01). The ORAC values/lipid peroxide levels in the venous plasma and amniotic fluid of PPROM pregnancy women were significantly higher than normal pregancy (P<0.01, P<0.01). The ascorbic acid levels in the venous plasma and amniotic fluid of PPROM pregnancy women were significantly higher than normal pregancy (P<0.05,P<0.01).
Conclusion: This result suggest that the increased inflammatory bioactivity, increased lipid peroxidation and decreased antioxidant activity may be involved in the pathophysiology of PPROM. Low levels of ascorbic acid appears to be an important determinant of PPROM.
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KEYWORD
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Preterm premature rupture of mambrane, Lipid peroxidation, Antioxidant ability, Amniotic fluid, Venous plasma
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